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M9650208.TXT
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1996-03-09
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Document 0208
DOCN M9650208
TI Cutaneous Acanthamoeba infection in the acquired immunodeficiency
syndrome: response to multidrug therapy.
DT 9605
AU Hunt SJ; Reed SL; Mathews WC; Torian B; University of California San
Diego Medical Center, USA.
SO Cutis. 1995 Nov;56(5):285-7. Unique Identifier : AIDSLINE MED/96157427
AB Acanthamoeba, a free-living ameba of soil and water, produces the rare
infections of granulomatous amebic encephalitis and amebic keratitis. We
report a 38-year-old white man with the acquired immunodeficiency
syndrome (AIDS) who experienced Acanthamoeba infection that presented as
multiple skin nodules without associated encephalitis. Histologic
examination revealed necrotizing granulomatous inflammation with
numerous amebic organisms that were cultured and identified as
Acanthamoeba group 2, probably Acanthamoeba castellani by monoclonal
antibodies. Results of in vitro susceptibility testing demonstrated
resistance to all six tested drugs. A partial clinical response,
however, was obtained with multidrug therapy.
DE *Acanthamoeba/CLASSIFICATION Adult Amebiasis/*DRUG THERAPY
Amebicides/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE Amphotericin
B/ADMINISTRATION & DOSAGE/THERAPEUTIC USE Animal Antibiotics,
Macrolide/ADMINISTRATION & DOSAGE/THERAPEUTIC USE
Antimetabolites/ADMINISTRATION & DOSAGE/THERAPEUTIC USE AIDS-Related
Opportunistic Infections/*DRUG THERAPY Case Report Drug Therapy,
Combination Flucytosine/ADMINISTRATION & DOSAGE/THERAPEUTIC USE Human
Male Rifampin/ADMINISTRATION & DOSAGE/THERAPEUTIC USE Skin Diseases,
Parasitic/*DRUG THERAPY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).